In a 2020 case report, a teenage girl intentionally overdosed on 45 kratom capsules (500mg each = 22.5 grams or 4/5 ounce). After suffering from severe depression, the 15 year old obtained the capsules from her father, and swallowed them in an attempted suicide. On exam, patient complained of dry mouth, dizziness, restlessness, palpitations, nausea, …
Teenager Attempts Suicide by Swallowing 45 Kratom Capsules Read More »
For audio of this interview as well as studies cited here see Kratom Science Podcast #45 KratomScience: You have your background in pharmacokinetics. What made you interested in going into that field? Dr. Abhisheak Sharma: So basically I did my PhD in 2015 and I moved to the States to do my post-doctoral studies with …
Inteview with Pharmacokineticist and Kratom Researcher Dr. Abhisheak Sharma Read More »
A team from the Department of Plant Biology at Michigan State University published the kratom genome, or the complete contents of genetic material in an organism. Using Rifat kratom trees grown in a greenhouse at the university, the team analyzed plant material to generate a draft assembly of mitragyna specioca for the first time. As …
A study out of University of Florida published in the journal ACS Pharmacology & Translational Science found that the potency of powder kratom may be due not only to the increased level of 7-hydroxymitragynine (7-HMG), but the way the 7-HMG metabolizes in human plasma (Kamble 2020). Fresh kratom consumed traditionally in Southeast Asia has been …
A research article in the journal Drug Testing and Analysis uncovered a flaw in previous examinations of kratom’s main alkaloid, mitragynine. The study, lead by University of Florida pharmacutics researcher Dr. Abisheak Sharma, stated: There is a possibility that earlier reported studies did not separate the four mitragynine diastereomers, resulting in over‐quantification of mitragynine in …
Levels of Kratom Alkaloid Mitragynine Were Likely Overestimated in Autopsies Read More »
Listen to this interview on Kratom Science Podcast #44 KratomScience: How do you pronounce your last name? Dr. Walter Prozialeck: Proh-jell-eck. It’s an old Ukrainian word that means “really bad golfer”. KS: *laughs* But I see you are a really good rugby player, it says on your Wikipedia page. WP: Well I used to be. …
Interview with Dr. Walter Prozialeck, Biomedical Educator and Kratom Researcher Read More »
DEPARTMENT OF HEALTH AND HUMAN SERVICESOffice of the SecretaryOffice of the Assistant Secretary for HealthWashington, D.C. 20201 AUG 16 2018 [stamped] The Honorable Uttam DhillonActing AdministratorDrug Enforcement AdministrationU.S. Department of Justice8701 Morrissette DriveSpringfield, VA 22152 Dear Mr. Dhillon: Pursuant to the Controlled Substances Act (CSA), 21 U.S.C. § 811, I am rescinding our prior recommendation …
Full Text of 2018 HHS Letter to DEA Rescinding Kratom Ban Recommendation Read More »
The United States House Committee on Appropriations has allocated the Agency for Healthcare Research and Quality (AHRQ) $500,000 towards kratom research for the year of 2021. The AHRQ was given a budget of $338,000,000 in total. “The Committee is aware of the potential promise of kratom-derived compounds for acute and chronic pain patients who seek safer …
In one of the first formal studies of its kind, if not the very first, a team from University of Florida cultivated 68 kratom trees and fertilized them at different rates, then measured for alkaloid content, chlorophyll, and total biomass. The study, “Effects of Nutrient Fertility on Growth and Alkaloidal Content in Mitragyna speciosa (Kratom)” …
UF Researchers First to Grow Kratom for Published Study Read More »
On August 16, 2018, Brett Giroir, Assistant Secretary of Health for the Department of Health and Human Services (HHS) sent a letter to then Acting Administrator of the Drug Enforcement Administration (DEA), Uttam Dhillon, rescinding a previous HHS recommendation that kratom should be federally outlawed. Pursuant to the Controlled Substances Act…, I am rescinding our …