The most studied alkaloids of the 40 identified in kratom are mitragynine (MG) and 7-hydroxymitragynine (7-OH). Recently, a team of researchers studied speciofoline (C22H28N2O5), a kratom alkaloid present in less than 1% of alkaloids. They found that speciofoline does not bind to mu-opioid receptors (MOR) like MG and 7-OH. They also found unexpectedly that levels …
What is speciofoline? The understudied kratom alkaloid Read More »
The term harm reduction refers to a public health strategy to reduce negative consequences resulting from activities such as illicit substance use and addiction. Whereas abstinence from dangerous drugs may be ideal, it’s not always realistic to expect abstinence from every addict at every stage of their addiction. Whether it’s handing out clean hypodermic needles …
Do you have attention deficit hyperactivity disorder (ADHD) and consume kratom? Or have you tried kratom for ADHD symptoms or side effects of medications? How did it make you feel? Did kratom interact positively or negatively with other meds? We’d love to hear from you. Please leave a reply at the bottom of this page …
Is kratom a drug, a medicinal herb, a dietary supplement, a “safe food”, a tea? These terms have a whole lot to do with social perception, a little to do with legal issues, and nothing to do with science. Kratom is a shrub that grows natively in Southeast Asia. Botanically, kratom comes from the Rubiaceae …
Mitragynine is the most abundant alkaloid in kratom. Kratom contains about 40 alkaloids that we know of. All of the alkaloids combined make up only 0.5-1.5% of the total leaf material. Estimates of percentage of mitragynine in alkaloids range from 12% in Malaysian kratom to 66% in Thai kratom. If alkaloids make up only 1% …
Citation Kruegel AC, Uprety R, Grinnell SG, et al. 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. ACS Cent Sci. 2019;5(6):992-1001. doi:10.1021/acscentsci.9b00141 Summary by KratomScience A study published in 2019 in the open access journal ACS Central Science found what may be a game changer in the pharmacology …
Study shows mitragynine metabolizes into 7-Hydroxymitragynine Read More »
Article Citation with Link to Full Text Harun N, Johari IS, Mansor SM, Shoaib M. Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats. Psychopharmacology (Berl). 2020;237(3):855-867. doi:10.1007/s00213-019-05418-6 Summary by KratomScience Rats were studied in two separate experiments: Experiment 1: Observing withdrawal in rats given morphine vs. rats given mitragynine Three …
An audio version of this interview can be found here. Dr. Marc Swogger is an associate professor at the University of Rochester Medical Center, Department of Psychiatry. Dr. Swogger is a social scientist and psychologist who studies substance use. He has co-authored multiple studies on the individual and public health effects of the use of …
Interview with Marc Swogger, University of Rochester social scientist Read More »
Wash your hands, stay in your house, avoid other people as much as possible. Covid-19 rates are climbing exponentially. Following these simple steps will save lives in your community. There’s no evidence kratom is a cure for the COVID-19 strain of Coronavirus. It is completely irresponsible to suggest otherwise. Anyone experiencing symptoms should call their …
Dirk Netter is the author of the first major German language book on kratom. Kratom – Ethnobotanik, Anwendung, Kultur (English: Kratom – Ethnobotany, Application, and Culture) is soon to be released by Nachtschatten Verlag (Nightshade Press), a publisher from Switzerland. In 2018, Netter founded HIPF, or Hochschulgruppe für interdisziplinäre psychedelische Forschung, translated to English: the …
Interview with Dirk Netter, author of the first German language book about kratom Read More »