47. Take it as a Tea with Hamilton’s Pharmacopeia Producer Soren Shade

Kratom Science Podcast
Kratom Science Podcast
47. Take it as a Tea with Hamilton's Pharmacopeia Producer Soren Shade
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Soren Shade grew up in the woods of West Virginia. Through a program for low-income, high-achieving students, he studied philosophy at Columbia University in New York. In his senior year he worked research assistant for Hamilton Morris and ended up as a producer on Season 3 of Hamilton’s Pharmacopeia, released earlier this year. Soren is …

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Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract
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Another study from University of Florida is the “first report that has simultaneously evaluated the systemic exposure of 11 kratom alkaloids following the administration of traditional and commercial kratom products” (Kamble, 2021). Researchers looked at the pharmacokinectics (how drugs move through the body and are metabolized) of alkaloids in rat plasma following the oral administration …

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46. Surviving Decades-Long Severe Chronic Pain with Dijon Evans

Kratom Science Podcast
Kratom Science Podcast
46. Surviving Decades-Long Severe Chronic Pain with Dijon Evans
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Dijon Evans is a survivor of severe chronic pain, and as past Kratom Science Podcast guest Nina Ajdin refers to her, a warrior. At 16 and working as a lifeguard, Dijon injured her leg trying to save a little boy from drowning. Doctors applied a cast too tight, and despite days of pleading, they would …

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Teenager Attempts Suicide by Swallowing 45 Kratom Capsules

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In a 2020 case report, a teenage girl intentionally overdosed on 45 kratom capsules (500mg each = 22.5 grams or 4/5 ounce). After suffering from severe depression, the 15 year old obtained the capsules from her father, and swallowed them in an attempted suicide. On exam, patient complained of dry mouth, dizziness, restlessness, palpitations, nausea, …

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Journal Club #15, Q&A Part 2: Kratom Legality, Kratom and Pharma, Dopamine Agonists, Libido, and Random Effects

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #15, Q&A Part 2: Kratom Legality, Kratom and Pharma, Dopamine Agonists, Libido, and Random Effects
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Note: Nothing in this podcast or on KratomScience.com is intended to be medical advice, nor should it be taken as such. We’re not medical doctors. Please don’t listen to podcasts for advice on what you should or should not put in your body. Dr. Cachat continues answering questions from February’s r/kratom Ask Me Anything. This …

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Inteview with Pharmacokineticist and Kratom Researcher Dr. Abhisheak Sharma

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For audio of this interview as well as studies cited here see Kratom Science Podcast #45 KratomScience: You have your background in pharmacokinetics. What made you interested in going into that field? Dr. Abhisheak Sharma: So basically I did my PhD in 2015 and I moved to the States to do my post-doctoral studies with …

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Journal Club #14, Q&A Part 1: Kratom and Liver Enzymes, Alcohol, Pain Management, and Serotonin

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #14, Q&A Part 1: Kratom and Liver Enzymes, Alcohol, Pain Management, and Serotonin
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Note: Nothing in this podcast or on KratomScience.com is intended to be medical advice, nor should it be taken as such. We’re not medical doctors. Please don’t listen to podcasts for advice on what you should or should not put in your body. For episode #14, Dr. Jonathan Cachat answers half of the remaining question …

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Study: 7-hydroxymitragynine Metabolizes into the More Potent ‘Mitragynine Pseudoindoxyl’ in Human Plasma

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A study out of University of Florida published in the journal ACS Pharmacology & Translational Science found that the potency of powder kratom may be due not only to the increased level of 7-hydroxymitragynine (7-HMG), but the way the 7-HMG metabolizes in human plasma (Kamble 2020). Fresh kratom consumed traditionally in Southeast Asia has been …

Study: 7-hydroxymitragynine Metabolizes into the More Potent ‘Mitragynine Pseudoindoxyl’ in Human Plasma Read More »