chemistry – Kratom Science

69. Dr. Christopher McCurdy and Dr. Brian Pearson on the Future of Kratom

Kratom Science Podcast

69. Dr. Christopher McCurdy and Dr. Brian Pearson on the Future of Kratom

00:00 / 1:02:51

Dr. Chris McCurdy is a medicinal chemist who has done groundbreaking research on kratom since 2004, starting at the University of Mississippi. In 2017 Dr. McCurdy moved to the University of Florida College of Pharmacy where he continues his research today with an expert team of pharmacologists, unlocking the function of kratom’s many alkaloids and …

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Journal Club #22: Accelerated Solvent Extracts of Kratom

Journal Club with Dr. Jonathan Cachat

Journal Club #22: Accelerated Solvent Extracts of Kratom

00:00 / 38:53

Neuroscientist Dr. Jon Cachat and host Brian Gallagher look at a study from University of Science in Malaysia that studies kratom extracts using various solvents: water, methanol, ethanol, and ethyl acetate. The technique they use, accelerated solvent extracting, uses less time and a lower amount of solvent for a safer and more environmentally friendly extraction …

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48. Plant Medicine from Food Waste with Andrew Tait

Kratom Science Podcast

48. Plant Medicine from Food Waste with Andrew Tait

00:00 / 43:01

Andrew Tait from Vancouver BC Canada got his PhD in chemistry at the University of British Columbia and founded Tait Labs in 2011. He studied traditional Chinese medicine and “realized a need to apply scientific rigor to traditional medicines in order prove their potency, safety and efficacy in the treatment of a wide range of …

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Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract

Journal Club with Dr. Jonathan Cachat

Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract

00:00 / 47:20

Another study from University of Florida is the “first report that has simultaneously evaluated the systemic exposure of 11 kratom alkaloids following the administration of traditional and commercial kratom products” (Kamble, 2021). Researchers looked at the pharmacokinectics (how drugs move through the body and are metabolized) of alkaloids in rat plasma following the oral administration …

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Study: 7-hydroxymitragynine Metabolizes into the More Potent ‘Mitragynine Pseudoindoxyl’ in Human Plasma

Leave a Comment / General, Research / By Brian

A study out of University of Florida published in the journal ACS Pharmacology & Translational Science found that the potency of powder kratom may be due not only to the increased level of 7-hydroxymitragynine (7-HMG), but the way the 7-HMG metabolizes in human plasma (Kamble 2020). Fresh kratom consumed traditionally in Southeast Asia has been …

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Levels of Kratom Alkaloid Mitragynine Were Likely Overestimated in Autopsies

Leave a Comment / General, Research / By Brian

A research article in the journal Drug Testing and Analysis uncovered a flaw in previous examinations of kratom’s main alkaloid, mitragynine. The study, lead by University of Florida pharmacutics researcher Dr. Abisheak Sharma, stated: There is a possibility that earlier reported studies did not separate the four mitragynine diastereomers, resulting in over‐quantification of mitragynine in …

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Journal Club #13: How Kratom Alkaloids Act on Brain Receptors

Journal Club with Dr. Jonathan Cachat

Journal Club #13: How Kratom Alkaloids Act on Brain Receptors

00:00 / 39:13

We all know the mitragynine and 7-hydroxymitraginine act on the mu-opioid receptor. But for episode #13 of Journal Club we talk about a study that looks closely at the binding affinity of various kratom alkaloids on the plethora of opioid and adrenergic receptors in the brain. How exactly does this work? How do different alkaloids …

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What is speciofoline? The understudied kratom alkaloid

Leave a Comment / General, Research / By Brian

The most studied alkaloids of the 40 identified in kratom are mitragynine (MG) and 7-hydroxymitragynine (7-OH). Recently, a team of researchers studied speciofoline (C22H28N2O5), a kratom alkaloid present in less than 1% of alkaloids. They found that speciofoline does not bind to mu-opioid receptors (MOR) like MG and 7-OH. They also found unexpectedly that levels …

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Journal Club #9: Speciofoline, the Understudied Alkaloid

Journal Club with Dr. Jonathan Cachat

Journal Club #9: Speciofoline, the Understudied Alkaloid

00:00 / 41:41

A study on kratom’s chemical composition asks, what does the little-researched kratom alkaloid speciofoline do? And what are the implications for drug interactions and the differences in alkaloid content in kratom products? The brand new study published last week in Scientific Reports examined the chemical composition of 53 kratom products and divided them into two …

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