metabolism

Kratom Interactions with Food, Drugs, and Dietary Supplements

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Many foods, drugs, and dietary supplements can interact with other foods, drugs, and dietary supplements. This can have various effects on the body ranging from barely noticeable to a toxic adverse event. Kratom can interact with multiple drugs and dietary supplements, and certain foods. Multiple studies have shown alkaloids in kratom inhibit cytochrome P-450 enzymes …

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Possible causes of kratom-related liver toxicities and deaths

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Herb-induced liver injury (HILI) is “a rare adverse reaction associated with the consumption of herbal products”. A review published in 2020 found 12,068 cases of herb-induced liver injury worldwide, as well as 46,266 cases of liver injury induced by the use of drugs (Teschke et al., 2021). Herbal and dietary supplements contribute to 20% of …

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50. The Kratom Genome with Julia Brose and Dr. Robin Buell

Kratom Science Podcast
Kratom Science Podcast
50. The Kratom Genome with Julia Brose and Dr. Robin Buell
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Brian welcomes Julia Brose, graduate student at Michigan State University and lead author of the study “The Mitragyna speciosa (Kratom) Genome: A resource for data-mining potent pharmaceuticals that impact human health”. She’s joined by Dr. Robin Buell, MSU Distinguished Professor of Plant Biology, who co-authored the study. We talk about the Rubiaceae family of plants, …

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Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #16: Bioanalysis of 11 Alkaloids in Kratom Tea vs. Commercial Extract
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Another study from University of Florida is the “first report that has simultaneously evaluated the systemic exposure of 11 kratom alkaloids following the administration of traditional and commercial kratom products” (Kamble, 2021). Researchers looked at the pharmacokinectics (how drugs move through the body and are metabolized) of alkaloids in rat plasma following the oral administration …

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Inteview with Pharmacokineticist and Kratom Researcher Dr. Abhisheak Sharma

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For audio of this interview as well as studies cited here see Kratom Science Podcast #45 KratomScience: You have your background in pharmacokinetics. What made you interested in going into that field? Dr. Abhisheak Sharma: So basically I did my PhD in 2015 and I moved to the States to do my post-doctoral studies with …

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Journal Club #14, Q&A Part 1: Kratom and Liver Enzymes, Alcohol, Pain Management, and Serotonin

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #14, Q&A Part 1: Kratom and Liver Enzymes, Alcohol, Pain Management, and Serotonin
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Note: Nothing in this podcast or on KratomScience.com is intended to be medical advice, nor should it be taken as such. We’re not medical doctors. Please don’t listen to podcasts for advice on what you should or should not put in your body. For episode #14, Dr. Jonathan Cachat answers half of the remaining question …

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Study: 7-hydroxymitragynine Metabolizes into the More Potent ‘Mitragynine Pseudoindoxyl’ in Human Plasma

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A study out of University of Florida published in the journal ACS Pharmacology & Translational Science found that the potency of powder kratom may be due not only to the increased level of 7-hydroxymitragynine (7-HMG), but the way the 7-HMG metabolizes in human plasma (Kamble 2020). Fresh kratom consumed traditionally in Southeast Asia has been …

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45. Dr. Abisheak Sharma, Pharmacokineticist and Kratom Researcher

Kratom Science Podcast
Kratom Science Podcast
45. Dr. Abisheak Sharma, Pharmacokineticist and Kratom Researcher
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Dr. Abisheak Sharma studied pharmacy and pharmacokinetics in India before coming to the United States to research under kratom expert Dr. Bonnie Avery. He now researches kratom with Dr. Christopher McCurdy at University of Florida as part of the Translational Drug Development Core. Dr. Sharma addresses the concern with kratom and other drug interactions, improved …

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Journal Club #13: How Kratom Alkaloids Act on Brain Receptors

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #13: How Kratom Alkaloids Act on Brain Receptors
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We all know the mitragynine and 7-hydroxymitraginine act on the mu-opioid receptor. But for episode #13 of Journal Club we talk about a study that looks closely at the binding affinity of various kratom alkaloids on the plethora of opioid and adrenergic receptors in the brain. How exactly does this work? How do different alkaloids …

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