mitragynine – Kratom Science

Isolated 7-hydroxymitragynine Now Being Sold in Tablets and Liquid Shots

Leave a Comment / General, News / By Brian

Companies are now selling isolated 7-hydroxymitragyinine in a grey marketplace that the Food and Drug Administration (FDA) refuses to regulate. Found in near-zero amounts in plain leaf kratom, 7-hydroxymitragyinine has been shown in animal studies to have enormous dependency potential. Obeng et al 2020 demonstrated that while mitragynine, kratom’s most abundant alkaloid, has “a complex …

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Journal Club #38: Mitragynine in Kratom Trees in Thailand

Journal Club with Dr. Jonathan Cachat

Journal Club #38: Mitragynine in Kratom Trees in Thailand

00:00 / 30:34

Thailand has recently decriminalized kratom after 79 years of prohibition. In today’s episode of Kratom Science Journal Club, Dr. Cachat and Brian look at a study funded in part by the Thai government that analyzed kratom trees growing in various regions of Thailand. The team measured mitragynine levels, accounting for variables in climate such as …

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Scientists study mitragynine levels in Thai kratom

Leave a Comment / General, Research / By Brian

In a study published in October in Frontiers in Plant Science, researchers collected leaves from kratom trees in various regions of Thailand to measure mitragynine (MG) levels, and to account for environmental variables that may influence the alkaloid content. The team from Kasetsart University in Bangkok found a range of mitragynine content, from 7.5 to …

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Journal Club #36: Mitragynine for Chemotherapy-Induced Pain

Journal Club with Dr. Jonathan Cachat

Journal Club #36: Mitragynine for Chemotherapy-Induced Pain

00:00 / 43:43

Dr. Jon and Brian look at a study (Farkas et al., 2022 https://doi.org/10.1016/j.ibneur.2022.08.007) in mice out of Temple University exploring whether mitragynine can help attenuate chemotherapy-induced peripheral neuropathic (CIPN). The team used oxaliplatin, a chemotherapy drug, to induce this condition in an equal number of male and female mice. Mitragynine was also combined with four …

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Is it a good idea to make a 7-hydroxymitragynine based drug?

Leave a Comment / General, News, Research / By Brian

A Vancouver drug company announced that it has filed a patent for a deuterated form of 7-hydroxymitragynine (7-HMG) called D7-h. The company, Nirvana Life Sciences Inc., intends to pursue D7-h as a pain relieving drug, citing 7-HMG’s partial opioid agonism, and the deuteration process that they say makes the drug last longer. A deuterated drug …

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81. Dr. Kirsten Smith of NIDA Returns

Kratom Science Podcast

81. Dr. Kirsten Smith of NIDA Returns

00:00 / 1:10:21

Dr. Kirsten Smith of National Institute on Drug Abuse (NIDA) joins us once again to talk about an upcoming comprehensive study that will include a detailed nationwide survey, testing of kratom samples, and testing select individual kratom consumers. We also cover several papers that Dr. Smith led or co-authored that have been published since her …

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Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects

Journal Club with Dr. Jonathan Cachat

Journal Club #28: Mitragynine Does Not Rely on 7-hydroxymitragynine for Pain Relief Effects

00:00 / 39:20

Dr. Cachat and host Brian Gallagher look at a groundbreaking study from University of Florida School of Pharmacy showing mitragynine has pain relieving effects independent of its metabolism into 7-hydroxymitragynine. This could be revolutionary in the study of kratom as a safer pain medicine. We go on to talk about the cannabis testing lab that …

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69. Dr. Christopher McCurdy and Dr. Brian Pearson on the Future of Kratom

Kratom Science Podcast

69. Dr. Christopher McCurdy and Dr. Brian Pearson on the Future of Kratom

00:00 / 1:02:51

Dr. Chris McCurdy is a medicinal chemist who has done groundbreaking research on kratom since 2004, starting at the University of Mississippi. In 2017 Dr. McCurdy moved to the University of Florida College of Pharmacy where he continues his research today with an expert team of pharmacologists, unlocking the function of kratom’s many alkaloids and …

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Study: Mitragynine does not rely on its metabolism into 7-hydroxymitragynine to produce pain relieving effects

Leave a Comment / General, Research / By Brian

In a new study by the team at University of Florida, scientists found that the metabolite 7-hydroxymitragynine does not account for the pain-relieving effects of its parent alkaloid, mitragynine (Berthold et al., 2021). Here we investigated the hotplate antinociception, pharmacokinetics, and tissue distribution of mitragynine and 7-hydroxymitragynine at equianalgesic oral doses in…mice to determine the …

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Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice

Journal Club with Dr. Jonathan Cachat

Journal Club #26: High Dose Mitragynine Causes Cognitive Impairment in Mice

00:00 / 39:13

Dr. JC and Brian look at a study out of University of Science, Malaysia. The comprehensive and detailed study in mice from University of Science, Malaysia revealed mitragynine in very high doses is an agonist (binds to and activates) cannabinoid receptor Type 1 (CB1). Mice administered with high-dose mitragynine demonstrated similar reward-seeking behavior and cognitive …

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