toxicity

Kratom Interactions with Food, Drugs, and Dietary Supplements

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Many foods, drugs, and dietary supplements can interact with other foods, drugs, and dietary supplements. This can have various effects on the body ranging from barely noticeable to a toxic adverse event. Kratom can interact with multiple drugs and dietary supplements, and certain foods. Multiple studies have shown alkaloids in kratom inhibit cytochrome P-450 enzymes …

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106. Is Kratom Safe or Unsafe?

Kratom Science Podcast
Kratom Science Podcast
106. Is Kratom Safe or Unsafe?
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Brian looks at a news report from Bedford, Texas where a diabetic man ended up in the ICU after long term, heavy kratom use including 8-10 “bottles” per day (presumably extract shots) as well as vaping kratom. Yes kratom vaping is actually a thing, and it apparently damaged his lungs. In comparison to the majority …

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Scientists review kratom-related toxic events

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Kratom has been consumed for at least four centuries in Southeast Asia, and likely longer. Southeast Asian drug policy expert Pascal Tanguay told Kratom Science about the earliest documented evidence he’s seen: “Kratom was referred to as a medicinal herb in Thai pharmacopeias dating from the 1650s, as was indicated for the treatment of stomach …

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Lawsuit Slams Kratom Industry; Antihistamine Combined with Kratom Extract May Have Caused Death

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The parents of a man who died after ingesting kratom extract are suing multiple kratom companies and the American Kratom Association (AKA). In a 45 page complaint, Dana and John Pope allege their 23 year old son, Ethan, died after purchasing and ingesting “one or more bottles” of OPMS extract from two stores in two …

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Possible causes of kratom-related liver toxicities and deaths

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Herb-induced liver injury (HILI) is “a rare adverse reaction associated with the consumption of herbal products”. A review published in 2020 found 12,068 cases of herb-induced liver injury worldwide, as well as 46,266 cases of liver injury induced by the use of drugs (Teschke et al., 2021). Herbal and dietary supplements contribute to 20% of …

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Pennsylvania House Democrats Compare Kratom to Heroin in Pseudoscientific Tweet

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On May 2nd, the Pennsylvania House Democratic Policy Committee @PADemPolicy posted on Twitter that it was “in Allentown with @RepSchlossberg for a roundtable on the Evolving Epidemic: Opioids and Treatment Options.” Then in a reply to this tweet, wrote “Kratom is widely available but suppresses breathing much the same way as heroin.” As anyone who …

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Journal Club #29: Kratom Toxicity and Medicolegal Issues, and the Cannabis Museum

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #29: Kratom Toxicity and Medicolegal Issues, and the Cannabis Museum
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For #29 of Kratom Science Journal Club, JC and Brian look at a 2019 report on toxicological events having to do with mitragynine. Does mitragynine increase the effects of other drugs? How toxic is kratom on its own? Other alkaloids have commonly been counted as mitragynine, so what are the ramifications? All this and other …

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Journal Club #22: Accelerated Solvent Extracts of Kratom

Journal Club with Dr. Jonathan Cachat
Journal Club with Dr. Jonathan Cachat
Journal Club #22: Accelerated Solvent Extracts of Kratom
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Neuroscientist Dr. Jon Cachat and host Brian Gallagher look at a study from University of Science in Malaysia that studies kratom extracts using various solvents: water, methanol, ethanol, and ethyl acetate. The technique they use, accelerated solvent extracting, uses less time and a lower amount of solvent for a safer and more environmentally friendly extraction …

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Hamilton Morris, Soren Shade, and Dr. Oliver Grundmann Talk Kratom and a New Survey

Kratom Science Podcast
Kratom Science Podcast
Hamilton Morris, Soren Shade, and Dr. Oliver Grundmann Talk Kratom and a New Survey
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Take the new anonymous kratom survey! tinyurl.com/kratomteasurvey Hamilton Morris, creator of Hamilton’s Pharmacopeia, and producer Soren Shade talk to University of Florida scientist and past Kratom Science Podcast guest Dr. Oliver Grundmann about his new anonymous research survey on kratom tea. All kratom consumers are invited to participate. Plus, how an overly positive kratom narrative …

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Teenager Attempts Suicide by Swallowing 45 Kratom Capsules

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In a 2020 case report, a teenage girl intentionally overdosed on 45 kratom capsules (500mg each = 22.5 grams or 4/5 ounce). After suffering from severe depression, the 15 year old obtained the capsules from her father, and swallowed them in an attempted suicide. On exam, patient complained of dry mouth, dizziness, restlessness, palpitations, nausea, …

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